CRP and heart failure: Additionally, the increase in TMAO concentrations is related to an increase in all-cause mortality [172], the incidence of major adverse cardio and cerebrovascular events (MACCEs) [173,174], major adverse cardiovascular events (MACEs) [10,172,175], hypertension prevalence [176], diabetes [177], cardiovascular events (CVEs) risk [9], heart failure [178] and CRP concentrations [179], but diastolic blood pressure, HDL-cholesterol, LDL-cholesterol, triglycerides, total cholesterol and BMI are irrelevant [180,181].