As the modulation of Jak3 functions is implicated in different therapies [33,34], the drugs used to modulate Jak3′s immune functions are associated with severe infection and metabolic dysregulation [35,36,37,38,39,40,41], and Jak3 inhibition in patients with chronic inflammation [42,43,44] also leads to metabolic dysregulation. The gene discussed is JAK3; the disease is inflammation.