JAK3 and Cognitive impairment: To demonstrate which tissue-specific Jak3 deficiency instigated such conditions, our data suggested metabolic-syndrome-associated cognitive impairment, as seen in global Jak3-deficient mice, due to intestinal epithelial cell-specific Jak3 deficiencies, where IEC-Jak3-KO mice showed significant increases in body weight with HFD and compromises in restoring blood glucose upon glycemic challenge (Figure 2).