Since our data in Figure 1 showed HFD also decreased Jak3 expression in the intestine of WT mice, and a reconstitution of these conditions using global Jak3-KO mice led to cognitive impairment, we determined whether the intestinal tissue-specific IEC-Jak3 had an impact on Jak3 expression in the brain of mice fed with HFD. Here, JAK3 is linked to Cognitive impairment.