As analogs of vitamin D are given as treatments for conditions like SHPT in CKD, the complications arising from the free hormone hypothesis, inconsistent 1,25(OH)2D3 regulation of megalin and the incompletely understood mechanisms of megalin regulation in disease and extrarenal tissues all suggest the need for additional research assessing the role of megalin in vitamin D homeostasis. Here, LRP2 is linked to chronic kidney disease.