The knockdown of PHGDH in gastric cancer cells (SGC-7901 and MGC-803) leads to an elevated apoptosis percentage [22], suggesting that these gastric cancer cell lines are sensitive to PHGDH depletion as cancer cells with expression of PHGDH were found to be uniquely sensitive to PHGDH knockdown [9]. The gene discussed is PHGDH; the disease is cancer.