In a similar vein, here we focused our attention on NF-κB and the RANK/RANKL/OPG signaling pathways in order to reveal the mechanism of action associated with arthritis-alleviating effects of a 50% ethanol extract of RsBBM using a rat adjuvant-induced arthritis model of human RA. The gene discussed is TNFRSF11A; the disease is rheumatoid arthritis.