CASP3 and neuroblastoma: In other studies, Szychowski and Wójtowicz [64] observed that TBBPA (100 nM–100 μM, 6 h of incubation) increased caspase-3 activity in mouse hippocampal neuronal cells, while Al-Mousa and Michelangeli [17] showed that TBBPA in the concentrations from 1 to 30 μM activated caspase-3 in SH-SY5Y neuroblastoma cell line.