STAT3 and primary effusion lymphoma: Apigenin caused primary effusion lymphoma cell death and autophagy, as well as a decrease in intracellular reactive oxygen species, according to Marisa Granato et al. Furthermore, as indicated by p53 silencing, apigenin stimulated p53, which promoted catalase, and blocked the signal transducer and activator of transcription 3, the most critical pro-survival pathway in primary effusion lymphoma [52].