VEGFA and retinal ischemia: The retinal microvasculature is progressively damaged in diabetic patients, resulting in various events such as retinal ischemia, the upregulation of hypoxia inducible factor-1, and vascular endothelial growth factor (VEGF) secretion, possibly progressing to PDR, which is diagnosed according to the presence of vascular lesions [1,2,3,4,5,6,7,8].