CD47 and diffuse large B-cell lymphoma: Berberine-induced CD47 inhibition increased the phagocytosis of macrophages, thus removing DLBCL cells in vitro and in vivo. A quantity of 30 μM berberine was used to treat U2932, LY1, and LY8 cells; the expression of CD47 was detected and berberine induced downregulation of CD47 in a time-dependent manner.