Berberine inhibits NF-B nuclear translocation in U266 multiple myeloma cells through Set9-mediated lysine methylation, which results in a drop in miR21 and Bcl-2 levels and triggers ROS production and apoptosis [56] and Berberine inhibited the cell viability of multiple myeloma cells and downregulated the expression of miR-19a/92a [214]. Here, SETD7 is linked to plasma cell myeloma.