The effect of berberine on the radiosensitivity of prostate cancer was investigated and findings revealed that berberine increased xenografts and radiosensitivity of prostate cancer cells in a dose-dependent way, and this was connected with the prevention of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor expression [115]. The gene discussed is HIF1A; the disease is prostate cancer.