DKK1 and metabolic syndrome: Another study on osteoporosis caused by metabolic syndrome showed that ATT lowered RANKL, sclerostin, DKK-1 and FGF-23 levels, which prevented the deterioration of trabecular bone microstructure and increased the ultimate load, Young’s modulus of elasticity, and decreased the ultimate strain of femur in the high-carbohydrate high-fat (HCHF) rats [82,83].