Additionally, many signaling pathways involved in the growth, proliferation, self-renewal, and differentiation of normal stem cells are abnormally activated or inhibited in tumorigenesis and in cancer initiation and development; these include the Wnt, Notch, NF-κB, and Hedgehog pathways, which regulate CSCs’ initial development, and which are all active in a wide range of human cancers, including MM [17]. This evidence concerns the gene NFKB1 and cancer.