CCND1 and gastric cancer: (1) Suppression of precancerous lesions: The polysaccharide fraction of Caulis Dendrobii inhibited 1-Methyl-2-nitro-1-nitrosoguanidine-induced precancerous lesions in gastric cancer rats by downregulating the gene expression of Wnt2β, Gsk3β, PCNA, CyclinD1, and β-catenin through inhibiting the Wnt/β-catenin signaling pathway [116].