In addition, polysaccharides also inhibit 1-methyl-2-nitro-1-nitrosoguanidine-induced precancerous lesions in gastric cancer rats by downregulating the gene expression of Wnt2β, Gsk3β, PCNA, CyclinD1, and β-catenin by inhibiting the Wnt/β-catenin signaling pathway [116]. This evidence concerns the gene PCNA and gastric cancer.