TNF and gastric cancer: (3) Regulating immune activity: The Ganoderma lucidum polysaccharide fraction enhanced the immunity and antioxidant activity of Nmethyl-N9-nitro-Nnitrosoguanidine-induced gastric cancer rats by reducing IL-6 and TNF-α levels and increasing levels of IL-2, IL-4, IL-10, SOD, CAT, and GSH-Px [86].