To validate whether overexpression of APOBEC3G could be used as a tool for risk stratification, univariate and multivariate Cox regression analyses were performed, and the AML-related factors such as age, gender, WBC count, BM/PB blast count, cytogenetic risk, FAB classification, and FLT3 and NPM1, which are easily mutated genes, were evaluated [2,4]. The gene discussed is NPM1; the disease is acute myeloid leukemia.