IFNG and irritable bowel syndrome: Kojima et al. [84,85] further investigated the relationship between other oral streptococci and aggravation of IBD exerting a DSS-induced colitis mouse model and the results suggested that S. sanguinis ATCC 10,556 and TW289 led to a noticeable worsening of DSS-induced colitis induced by boosting IFN-γ secretion after intruding into the bloodstream.