The diagnostic performance of serum cathepsin B and PKa for assessing significant liver fibrosis (≥F2) has proved superior to other serum biomarkers previously described [34], such as type IV collagen (AUROC = 0.73–0.83), hyaluronic acid (AUROC = 0.82–0.92), laminin (AUROC= 0.542–0.82) and Mac-2 binding protein glycan isomer, M2BPGi (AUROC = 0.774) [35]. This evidence concerns the gene CTSB and Hepatic fibrosis.