The main independent predictors for VTEs were age, with an adjusted hazard ratio (aHR) of 1.05/per year, and coagulopathy, certified by a spontaneous prolongation of the prothrombin time > 3 s or of the activated partial thromboplastin time (aPTT) > 5 s, with an aHR of 4.1 [47]. Here, F2 is linked to blood coagulation disease.