E. faecalis possesses many virulence factors, such as enterococcal surface protein (esp), gelatinase (gelE), aggregation substance (asa1), cytolysin B (cylB), and endocarditis-specific antigen A (efaA) gene, ArgR family transcription factor (ahrC), endocarditis and biofilm-associated pili (ebpA), enterococcal polysaccharide antigen (epal), epal and OG1RF_11715 (epaOX), and (p)ppGpp-synthetase/hydrolase (relA) genes [47,48,49,50,51,52,53,54,55]. The gene discussed is RELA; the disease is endocarditis.