In addition to the KRAS gene, the two colon cancer cell lines also differ in several other cancer critical genes; moreover, the HCT116 cell line contains high proportions of dormant cells (G0/G1 phase), while the HT29 cell line presents more cells in active phases of the cell cycle (S/G2/M), which can be more efficiently attacked by anticancer agents [28]. The gene discussed is KRAS; the disease is malignant colon neoplasm.