SIRT1 and Cognitive impairment: The results of Shan Gao and colleagues showed that exogenous H2S alleviated SD-induced cognitive impairment by ameliorating working memory impairment in Y-maze test, cognitive dysfunction in the novel object recognition test, location memory deficit in object location test, and spatial learning and memory disorder in the Morris water maze test, which were reversed by the inhibition of Sirt-1 by Sirtinol (an inhibitor of Sirit-1).