AKT1 and breast cancer: For example, the representative formula of Yanghe decoction in TCM was considered an important prophylactic and therapeutic treatment for breast cancer [17], which inhibits proliferation, reduces metastasis, and induces the apoptosis of breast cancer cells; its mechanism may be related to its inhibition of the activation of PI3K/Akt/NF-kB signaling pathway [18,19,20].