LEP and Insulin resistance: These results are in accordance with those reported in the present study and with some pathophysiological mechanisms that may explain the observed changes in BP and their relationship with those in WC, such as a sympathetic nervous system overactivation, a stimulation of the renin–angiotensin–aldosterone system, an alteration in adipose-derived cytokines such as leptin, and insulin resistance, as well as structural and functional renal changes [45,46].