Among those 17 genes have already been shown to have a significant effect on atherosclerosis either as human CAD GWAS candidate gene (LDLR, PLAUR, RGS1, TRIB1 and TSC22D2) or in engineered mouse models (Ccl7, Edn1, Erg1, Erg2, Gdf15, Il1b, Ldlr, Mmp12, Nr4a1, Nr4a2, Plaur, Rgs1, Serpine1, Sgk1, Trib1, Tsc22d2, Vcam1) [18,22,33,43,44,45,46,47,48,49,50,51,52,53,54,55]. The gene discussed is EDN1; the disease is atherosclerosis.