However, in another study, inserting a human variant of sEH that more preferentially translocates to peroxisomes in mice decreased ischemia-induced injury [62], suggesting a complex role of sEH in cerebrovascular function depending on its sub-cellular organelle-level localization, perhaps due to its actions on, or metabolism of, different subsets of PUFA oxylipins. The gene discussed is EPHX2; the disease is ischemia.