Furthermore, several other inherited conditions are associated with alterations in the metabolism of iron and iron overloads, such as iron deficiency–iron refractory anemia (IRIDA, caused by pathogenic variants in TMPRSS6), aceruloplasminemia or hypoceruloplasminemia, and iron-loading anemias [3,24,26,27]. The gene discussed is TMPRSS6; the disease is aceruloplasminemia.