Intriguingly, it has been reported that mice lacking one or two functional copies of the mitoferrin 1 (Mfrn1) gene in hepatocytes, when fed ALA, show an increase in protoporphyrin IX production, with histological liver alterations (chronic cholestasis, early-to-advanced fibrosis) reminiscent of erythropoietic protoporphyria (EPP) [58]. Here, SLC25A37 is linked to erythropoietic protoporphyria.