INS and metabolic syndrome: Epidemiological data and clinical trials suggest that a 0.026 mmol L−1 increase in LDL cholesterol causes a 1% increase in coronary risk [88] and that for every 1% lowering of serum cholesterol levels, the risk of developing coronary heart disease is reduced by 2–3% and reducing insulin levels reduces the risk of developing insulin insensitivity and metabolic syndrome.