A possible anticancer mechanism (antiproliferative) of Avn (from oat grains: Avn, Avn-C, methylated derivative of Avn-C (CH3-Avn-C)) is by suppression of cyclooxygenase-2 (COX-2) and prostaglandin (PGE2) activity in colon endothelial cell macrophages [102]; they significantly inhibited the proliferation of human colon cancer cell lines (COX-2-positive HT-29, Caco-2, and LS174T, and COX-2-negative HCT116). This evidence concerns the gene PTGS2 and colonic neoplasm.