GAD2 and type 2 diabetes mellitus: Since no change in the GABA synthesizing enzyme (GAD65) was found in healthy versus type 2 diabetes-affected human islets via immunostaining [9], several other factors may influence this parameter including lower GABA synthesis as mentioned by Menegaz et al. through the increased presence of either the inactive form of GAD65 or its inhibitor and more GABA metabolism over GAD65 activation.