Recent studies have demonstrated that activation of FXR in the testis can induce the transcription of dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene-1 (DAX-1) or small heterodimer partner (SHP) to repress steroidogenesis in pubertal mice [31,75]. The gene discussed is NR0B2; the disease is chronic primary adrenal insufficiency.