MAT2A and hepatocellular carcinoma: The balance between MAT1A and MAT2A has been related to increased metastatic activity and poor prognosis of HCC through the activation of RAS/ERK (Rat sarcoma/Extracellular regukated kinase), PI3K/AKT (Phosphatidylinositol-3-kinase/Serine-threonine protein kinase) and NF-κB (Nuclear Factor NF-kappa-B) pathways, providing proliferative and survival advantages to tumoral cells [120].