GNMT and neoplasm: Besides, in GNMT −/− tumors, cell pathways involved in cell proliferation and tumor formation including Ras and JAK/STAT (Janus kinase/Signal Transducer and Activator of Transcription) signaling are activated, and suppressors of these pathways (RASSF1, RASSF4, SOCS and cytokine-inducible SH2-protein) are inhibited.