F8 and Thrombocytopenia: This theory supports that thrombocytopenia is an early sign of endotheliopathy in disseminated or regional vascular disease, and the evidence of the activated ULVWF path of hemostasis can be confirmed easily by endothelial markers, such as the overly expressed ULVWF/VWF antigen and the elevated activity of FVIII, and especially with insufficient ADAMTS13 activity [5,6].