ADAMTS13 and Thrombocytopenia: In arterial edotheliopathy, if mild to moderate ADAMTS13 insufficiency is present in an individual due to a heterozygous mutation or the single nucleotide polymorphism of the ADAMTS13 gene, or due to the excess release of ULVWF from ECs over the ADAMTS13 capacity, TTP-like syndrome is produced with the triad of thrombocytopenia, MAHA, and MODS.