Previous studies have suggested that in obesity and type 2 diabetes, accumulation of lipid intermediates, such as triacylglycerol, diacylglycerol, and ceramide have a deleterious effect on skeletal muscles insulin sensitivity, thus increasing fatty acid oxidation in the muscle should decrease the accumulation of lipid intermediates and improve insulin secretion [25]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.