Our group is well-acquainted with the importance of genes involved in the circadian cycle, having observed a significant association between the CLOCK-rs4580704 single-nucleotide polymorphism (SNP) and type 2 diabetes (T2D) incidence in 3671 non-T2D Prevention with Mediterranean Diet (PREDIMED) study participants, suggesting a gene effect modulation induced by the Mediterranean diet [3]. The gene discussed is CLOCK; the disease is type 2 diabetes mellitus.