Inherited obesity and polygenic obesity (stemming from multiple and synergistic polymorphisms) are thought to involve brain, signaling, and nervous system genes such as NTRK2, KCNQ1, MRAP2, and ADCY3 that regulate satiety and thermo-caloric energy balance (Supplementary Table S1) [143]. This evidence concerns the gene MRAP2 and obesity due to melanocortin 4 receptor deficiency.