In a meta-study examining 15 reports of 5421 total cases of type 2 diabetes, IL-6 was strongly related, a finding supported by a subsequent multi-ethnic analysis of 260,614 diabetics which found that Asp358Ala mutations in the IL-6 receptor (IL-6R) were correlated with type 2 diabetes [107]. Here, IL6R is linked to type 2 diabetes mellitus.