INS and obesity due to melanocortin 4 receptor deficiency: Adiponectin, a related adipokine (protein hormone) released from WAT, modulates insulin sensitivity through AdipoR1 and AdipoR2 receptors on diverse cell types and was found important for blunting the transition from to MUHO from MHO in studies of 822 US adults as well as 1137 children with obesity in China (Figure 2) [77,78,79].