Further investigation into the mechanisms by which CYP4Z1 contributes to tumorigenesis revealed that expression of the pseudogenes CYP4Z1-3′UTRs and CYP4Z2P synergistically increased tumor angiogenesis in breast cancer partly via the activation of the PI3K/Akt and ERK1/2 pathways [36]. This evidence concerns the gene MAPK3 and breast carcinoma.