Univariate analysis showed that hypoalbuminemia (an albumin level of < 25 g/L) and a white blood cell count of ≥ 15 × 103/μL were the laboratory parameters with a significant impact on CDI occurrence in COVID-19 patients (39.57% vs. 21.71%, p = 0.019 and 43.86% vs. 28.94%, p = 0.021, respectively). Here, ALB is linked to clostridium difficile infection.