The multivariate analysis demonstrated that hospitalization in the preceding two months (OR: 2.364 (95% CI: 1.328–4.786), p = 0.021), the administration of antibiotics during the hospital stay (OR: 1.496 (95% CI: 1.039–1.961), p = 0.025), and an albumin level of ≤ 25 g/L (OR: 4.153 (95% CI: 2.368–6.412), p = 0.019) were independent risk factors for CDI development in patients with COVID-19. Here, ALB is linked to clostridium difficile infection.