From the available data, the most common LHON-causing mutation, m.11778G > A (MT-ND4), was diagnosed in 5 out of 17 patients (29.4%) in LUHS, which is in contrast to global statistics, in which this mutation is found in about 60% of diseased Northern Europeans and 90% of diseased Asians [7,30,31,34]. This evidence concerns the gene MT-ND4 and Leber hereditary optic neuropathy.