ATV inhibited HIF-1α protein expression for increased radiosensitivity of prostate cancer cells [89];atorvastatin and caffeine induced apoptotic death by downregulating phospho-Akt, phospho-Erk1/2,and anti-apoptotic Bcl-2 [90];activation of LC3 transcription by atorvastatin induced autophagy in prostate cancer cells [91]Decreased PSA velocities after statin treatment in castration-resistant prostatic cancer patients [65]. The gene discussed is MAPK3; the disease is Familial prostate cancer.