Both the KrasLSL.G12D/+ and the Pdx1-Cre (KC) mouse models of cerulean-induced inflammatory pancreatitis and the KrasLSL.G12D/+, Tp53R172H/+, and Pdx1-Cre (KPC) animal types of advanced pancreatic cancer responded to mebendazole administration by reducing pancreas weight, dysplasia, and intraepithelial neoplasia development. The gene discussed is PDX1; the disease is intraepithelial neoplasia.