Given that different types of cancer behave and respond differently to various types of treatment, understanding the effect of TRPV4 activation in OSCC by using a TRPV4 agonist or combining the use of a TRPV4 agonist with an anticancer drug, such as cisplatin, will be of great importance, especially in these times when the options for cancer treatment have diversified. Here, TRPV4 is linked to cancer.