To study the effects of decreased OCT-1 expression on breast cancer cell resistance to chemotherapeutics, MDA-MB231 cells with decreased OCT-1 expression were treated with Doxorubicin or docetaxel in the concentration of 1 μg/mL or 2 μg/mL, respectively, for 24 h. Here, POU2F1 is linked to breast carcinoma.