To our best knowledge, we are the first to identify α-MG as an inhibitor of cancer metastasis by targeting and suppressing periFN assembly on suspended tumor cells in the circulation without triggering cell apoptosis (Figure 1, Figure 2 and Figure 3), which was rationalized by the increased AKT phosphorylation (Figure 3D) as a survival signal [30]. The gene discussed is AMELX; the disease is cancer.