At the spinal cord level, Wu, X.P. et al. found the protective role of miR-329 through the LPAR1-dependent LPAR1/ERK signal transduction pathway [35]; Elramah S. et al. verified the downregulation of miR-124 in a mouse model of cancer pain, which could inhibit synaptopodin, which is a key protein for synaptic transmission [8]; and Liu, M. showed the downregulation of spinal miR-135-5p in BCP mice, which could inhibit astrocyte-mediated neuroinflammation by blocking the JAK2/STAT3 signaling pathway [9]. The gene discussed is SYNPO; the disease is cancer.