Then, an assay of miR-155-5p expression showed that the miR-155-5p sponge could effectively knock down miR-155-5p in the lumbar spinal cord of bone cancer pain rats (multiple comparisons: adjusted p = 0.0079, BCP + NC vs. sham + NC; adjusted p = 0.0346, BCP + NC vs. BCP + sponge; Figure 6B). This evidence concerns the gene OPN1SW and bone neoplasm.