The genetic alterations present in dysplastic nevi include: (i) intermediate microsatellite instability between benign nevi and CM; (ii) allelic losses at 1p, 9p, and 17p; (iii) DNA abnormalities similar to superficial spreading melanoma; (iv) V600E mutation in the BRAF gene; (v) loss of tumor suppressor genes (TP53 and CDKN2A) and alterations in oncogenes (RAS), though at lower frequencies than in CM [21,27]. The gene discussed is TP53; the disease is melanoma.