Aside from p16 in cancer, although only p21-positive cells were able to prevent radiation-induced osteoporosis [86], p16 deletion inhibited oxidative stress, osteocyte senescence, and osteoclastic bone resorption, which led to osteogenesis and osteoblastic bone formation, indicating a promising mechanism to prevent estrogen deficiency-induced osteoporosis [137]. The gene discussed is CDKN2A; the disease is cancer.