Receptor-interacting kinase 3 (RIPK3), a serine–threonine kinase implicated in non-caspase dependent apoptosis termed as necroptosis that leads to ARDS after trauma and sepsis [71]; increased serum levels of RIPK3 are reported in morbid cases of COVID-19 [72]. The gene discussed is RIPK3; the disease is acute respiratory distress syndrome.