Ellinghaus et al., reported a significant association of variants in six candidate genes at chromosome 3p21.31, including Solute Carrier Family 6 Member 20 (SLC6A20), Leucine Zipper Transcription Factor Like 1 (LZTFL1), C-C Motif Chemokine Receptor 9 (CCR9), C-X-C Motif Chemokine Receptor 6 (CXCR6), FYVE and Coiled-coil Domain Autophagy Adaptor 1 (FYCO1), and X-C Motif Chemokine Receptor 1 (XCR1) and the ABO blood group locus at 9q34.2, with respiratory failure in COVID-19 patients from Italy and Spain [20]. This evidence concerns the gene XCR1 and COVID-19.