Arachidonate 5-Lipoxygenase Activating protein (ALOX5AP) encodes for 5-LOX activating protein (FLAP), an activating cofactor for the lipid mediator, Arachidonate 5-lipoxygenase (ALOX5) that generates leukotriene B4 (LTB4) associated with poor respiratory pathologies such as pneumonia, ARDS, and severe lung injury [62,63]. This evidence concerns the gene ALOX5 and acute respiratory distress syndrome.