Already rare pathogenic single nucleotide variants in genes governing host immunity, such as Toll Like Receptor 7 (TLR7), Toll Like Receptor Adaptor Molecule 1 (TICAM1), Interferon Regulatory Factor 3 (IRF3), and Interferon Alpha and Beta Receptor Subunit 1 (IFNAR1) are reported in severe cases of COVID-19, including in young patients without pre-existing comorbidities [39,40]. The gene discussed is IRF3; the disease is COVID-19.