PDE8B and pulmonary emphysema: This revealed prominent associations at Von Willebrand Factor A Domain containing 8 (VWA8; 13p11.2), Phosphodiesterase 8B (PDE8B; 5q13.3), CTSC (11q14.2), Thrombospondin Type 1 Domain containing 7B (THSD7B; 2q22.1), Serine–Threonine kinase 39 (STK39; 2q24.3), F-box Protein 34 (FBXO34; 14q22.3), Ribosomal Protein L6 Pseudogene 27 (RPL6P27; 18p11.31) and Methyltransferase 21C, AARS1 Lysine (METTL21C; 13q33.3) that are expressed in the lung and associated with lung surface tension, airway obstruction, emphysema, T-cell mediated inflammation, and inflammatory cytokines [31].