CD27 and head and neck squamous cell carcinoma: At the same time, the presence of atypical memory B cells (CD27-IgM-IgD-) and CD24hi/CD38hi Breg cells in lymph nodes remote from the tumor nodules in patients with HNSCC correlated with a low histological grade of the tumors and less pronounced infiltration of sentinel lymph nodes, possibly regarded as favorable prognostic indicators [94].