Kou et al. [127] evidenced heterogeneity in the peroxisomal distribution in neurons of patients with AD, which was concentrated in the soma and absent in the dendrites, implying that Tau does not allow the correct transit of these organelles, being an abnormally phosphorylated cytoskeleton protein, the possible cause of the increase in the oxidizing environment. The gene discussed is MAPT; the disease is Alzheimer disease.