Considering that TBC1D16 has been previously shown to be involved in melanoma metastasis, Qi et al. studied whether other TBC proteins are involved in this process and identified the upregulation of TBC1D4, TBC1D14, TBC1D16, TBC1D7, and TBC1D10A and the downregulation of TBC1D24 proteins. The gene discussed is TBC1D16; the disease is melanoma.