They compared the transcription levels of these genes with the TCGA melanoma dataset and observed that the relative mRNA expressions of TBC1D10C, TBC1D19, TBC1D16, TBC1D13 and TBC1D7 were higher and expression of TBC1D15 was lower, while for TBC1D8B, there were no differences between the melanoma samples and normal tissues. The gene discussed is TBC1D16; the disease is melanoma.