Determining the expression of autophagy and beclin 1 regulator 1 (AMBRA1) and loricrin, two markers of epidermal differentiation, in the peritumoral epidermis can be useful in the further stratification of patients with AJCC stage I melanomas, as the decrease in AMBRA1 and loricrin expression is correlated with a high risk of metastasis [53]. The gene discussed is AMBRA1; the disease is melanoma.