EGFR and neoplasm: Correspondingly, EGFR is overexpressed in 80–90% of LSCC tumors, for the first time quantitatively evaluated in fmole/mg/protein on fresh tumor tissue sample in our previous preliminary study [38] and it resulted associated with poor relapse-free survival (RFS) and OS [34], lower metastasis-free survival [39] in specific laryngeal site cancers.