Therefore, the hypothesized deficiency in BDKRB2 stimulation in COVID-19 patients, which may result in a cytosolic calcium concentration decrease, could be mitigated through the SSRI antidepressant-mediated agonistic stimulation of Sig1-R, especially since this is accompanied by an increase in serotonin concentrations (Table 2) [40,41,42,43]. The gene discussed is SIGMAR1; the disease is COVID-19.