Mostly negative markers are CD34, Desmin, Wilms’ tumor protein (WT-1), smooth muscle antibody (SMA), MyoD1, S100, paired-box factor 8 (PAX8—regularly positive in renal cell carcinoma) and synaptophysin [17,31,43,44,45,46,47,48]. The gene discussed is WT1; the disease is renal cell carcinoma.