MAPK3 and cancer: Angiogenesis is a fundamental process in the growth and progression of tumors, and miR-197 promotes angiogenesis in cancer by increasing the VEGF-A/VEGFR2 pathway by binding to the CYP4Z2P and CYP4Z1 genes [42], and by activating the PI3K/pathways AKT and ERK1/2 [26].